Manufacturing of ChiroRab™

Highly immunogenic strain of rabies virus

Flury-Low Egg Passage (LEP)-C 25’ virus strain

Specific pathogen-
free eggs (SPF) fibroblasts do not contain vertically transmitted pathogens, oncogenic DNA and laterally transmitted avian infections

Propagation of virus in primary chick-embryo fibroblast cells

Harvesting of virus in the tissue-culture fluid

Inactivation of virus with 0.025% beta-propiolactone

Purification step after inactivation to produce a highly purified vaccine,
which greatly reduces the risk of hypersensitivity reactions

Purification and concentration by continuous density-gradient centrifugation

Addition of buffer and stabilizer